Now more-or-less confirmed via MTV, the new Spider-Man will have mechanical webshooters as opposed to biological webbing.
It's an incredibly minor detail, the definition of fan-only concern (see also: Captain America's wings, Hulk's purple pants) - theoretically important to the storytelling and characterization i.e. increased-tension and Peter Parker: Science Whiz concept but not exactly make-or-break stuff.
Still, make a note of it: This is the first thing the reboot has - potentially - done "better" than the originals. So, that's something of a landmark.